目的 制备胃苏微乳离子敏感型凝胶,并对其进行质量评价。方法 在单因素、伪三元相图的基础上,结合星点设计-响应面法优化挥发油微乳凝胶的处方组成,通过粒径,黏度,电位,柚皮苷,橙皮苷,新橙皮苷含量对最终处方进行评价。结果 胃苏微乳离子敏感凝胶的最佳处方配比为:挥发油3 g、聚氧乙烯氢化蓖麻油9 g、聚乙二醇-400 3 g、0.3%去乙酰结冷胶溶液,制成333 mL微乳凝胶。理化性质结果:微乳凝胶外观澄清;粒径20.14 nm,Zeta电位-4.04 mV,pH值5.43,黏度65 mPa·s,柚皮苷、橙皮苷、新橙皮苷含量分别为6.122 4,2.094 1和4.277 mg·mL-1。结论 胃苏微乳凝胶制备工艺合理、可行,成品稳定。
Abstract
OBJECTIVE To design and evaluate the formula of Weisu microemulsion-ion sensitive gel. METHODS The prescription of microemulsion-ion sensitive gel was conducted on the basis of single factor method and pseudotemary phase diagram method combining with central composite design-response surface methodology. The final formulation was evaluated by particle size, viscosity, potential, contents of naringin, hesperidin and neohesperidin. RESULTS The optimum prescription ratio of Weisu microemulsion-ion sensitive gel was as following:volatile oil 3 g, RH-40 9 g, PEG-400 3 g, 0.3% deacetylated gellan gum made into 333 mL microemulsion gel. The results of physicochemical properties showed that microemulsion gel appearance was clear. The particle diameter was 20.14 nm. The Zeta potential was -4.04 mV. pH value was 5.43. The contents of naringin, hesperidin and neohesperidin are respectively 6.122 4, 2.094 1, 4.277 mg·mL-1. CONCLUSION The preparation process of Weisu microemulsion gel is reasonable and feasible. The prepared microemulsion gel is system are stable.
关键词
胃苏微乳离子敏感凝胶 /
制备工艺 /
伪三元相图 /
星点设计-效应面优化法
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Key words
Weisu microemulsion-ion sensitive gel /
preparation technology /
pseudotemary phase diagram /
central composite design-response surface methodology
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中图分类号：
R944
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参考文献
[1] ZHAO Y. Identification of hesperidin and naringin in Weisu granules by TLC [J]. Strait Pharm J(海峡药学), 2016, 28(1):73-75.
[2] WU Y M, CHEN X L, TANG H Y, et al. Preparation and quality evaluation of shortstalk monkshood root total alkaloids in microemulsion gel[J]. Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2016, 22(20):10-13.
[3] SABALE V, VORA S. Formulation and evaluation of microemulsion-based hydrogel for topical delivery[J]. Int J Pharm Invertig, 2012, 2(3):140-149.
[4] JIANG Q L, LIU L H, HUANG R X, et al. Study on the formulation of tanshinone microemulsion containing salvianolic acid [J]. Mod Tradit Chin Med Mater Med World Sci Technol(世界科学技术-中医药现代化), 2016, 18(3):498-504.
[5] YUAN X, LIU X, HAO W Q, et al. Research on the preparation and in-vitro release of nobiletin microemulsion ion-sensitive gel [J]. J Chin Med Mater(中药材), 2016, 39(10):2290-2294.
[6] LI X F, WANG Q R, CHEN M, et al. Study on the rheological and gelation properties of menthol nasal in situ gel[J]. J Navy Med(海军医学杂志), 2018, 39(3):214-218.
[7] WANG F, WEN Y, BAI T. The composite hydrogels of polyvinyl alcohol-gellan gum-Ca2+ with improved network structure and mechanical property[J]. Mater Sci Eng C, 2016, 69:268-275.
[8] LI R Q, MA C X, FEI Y Y, et al. Progress in gastro retentive drug delivery system[J]. Centr South Pharm(中南药学), 2018, 16(9):76-80.
[9] XUE H J, TANG H Z, ZHANG Q, et al. Preparation and evaluation of artemether oral microemulsion in situ gel[J]. Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2018, 24(9):29-36.
[10] LUO H. Screening of effective parts from Sanjiu Weitai and development of the oral in situ gels [D]. Guangdong:Southern Medical University,2013.
[11] PAPADIMITRIOU V, PISPAS S, SYRIOU S, et al. Biocompatible microemulsions based on limonene:formulation, structure, and applications[J]. Langmuir, 2008, 24(7):3380-3386.
[12] LIU K P, CHENG S Y, YU L N, et al. Preparation and quality evaluation of self-microemulsion of total valepotriates invalerianae Jatamansi Rhizoma Et Radix [J]. Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2018, 24 (11):16-21.
[13] JIANG F, WANG Y, YAN J L, et al. Preparation and in vitro antibacterial effect of citronellol microemulsion gel[J]. Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2017, 23(20):8-13.
[14] TIAN X, FAN Y Z, SUN Y, et al. Optimization of artemether self-microemulsifying drug delivery system by central composite design-response surface methodology[J]. J Int Pharm Res(国际药学研究杂志), 2016, 43(5):966-970.
[15] WANG Y, LI M S, WU R C, et al. Optimization of preparation of sinomenine PLGA nanoparticles by central composite design-response surface methodology[J]. Tradit Chin Drug Res Pharmacol(中药新药与临床药理), 2017, 28(2):232-237.
[16] XIAO Z L, ZHAO R Z, LU C J. Preparation and quality evaluation of glycyrrhetinic acid microemulsion[J]. Chin Tradit Pat Med(中成药), 2016, 38(1):187-190.
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脚注
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基金
四川省大学生科研创新训练计划项目资助(2017097)
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